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KMID : 0948320050050010077
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Konyang Medical Journal
2005 Volume.5 No. 1 p.77 ~ p.82
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Comparison of Pulmonary Function and Level of Immunoglobulin E Between Tuberculous Destroyed Lung and Chronic Obstructive Pulmonary Disease
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Kim Jung-Kyu
Son Ji-Woong
Na Moon-Jun
Choi Eu-Gene
Lee Won-Young
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Abstract
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Objectives: Severe pulmonary tuberculosis causes impairment of lung function. Some patients show elevated serum Ig E but there is no knowledge about this. In this study, we performed this study to understand the change of lung function by comparison with chronic obstructive pulmonary disease (COPD) and the role of increased serum Ig E in TDL.
Method: We evaluated lung function including postbronchodilator response and serum level of IgE in TDL group (n=30) and COPD group (n=30) during stable state at least 6 months, and we compared each parameters of TDL with COPD.
Results: In TDL, FVC was declined much more than COPD (2.20±0.76 L vs. 2.61±0.81 L, p<0.05). There was not any statistical difference in FEV1 (>0.05), but FEV1 in TDL group tend to be lower than in COPD group. Also TLC and RV were reduced in TDL with statistical significance, too (5.14±1.50 L vs. 6.66±1.68 L, 2.74±1.02 L vs. 3.96± 1.58 L, p<0.05). Serum eosinophil and IgE had shown no significant difference between two groups. Impariment of lung function of Garde II (more than half of one lung) was more severe than Grade I (less than half of one lung). FVC of Grade II group was 1.79±0.49 L, it was lower significantly than Grade I group, 2.74±0.73 L (p<0.001).
Conclusion: TDL is a compound of bronchiectasis, emphysema and fibrosis of parenchyma. So, abnormality of lung function is consisted with obstructive and restrictive disorder. Severity of disorder, which is more severe than COPD, shows correlation with extent of detroyed lung volume. Effect of bronchodilator is minimal. Elevation of serum IgE in some patients was not associated with reversibility of bronchi, it is thought to be non-specific findings. More investigations about TDL and bronchiectasis are needed.
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KEYWORD
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TDL, COPD, Lung function, lgE
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